... and just in time for the 6th Annual Southeastern Parkinson Disease Conference in Atlanta, Georgia from October 14-16.FOR IMMEDIATE RELEASEInnovo Publishing LLC Releases Carson and His Shaky Paws Grampa by Kirk Hall.Summary/Description: Innovo Publishing LLC released Carson and His Shaky Paws Grampa, Book 1 in the Shaky Paws Grampa series. Shaky Paws is a story about the relationship and love between a seven-year-old boy and his grandfather who has Parkinson’s disease and essential tremor. This book is available now in the U.S. and internationally in hardback, paperback, Apple iBook, Amazon Kindle, Barnes and Noble Nook, and Google Android editions.Memphis, TN – October 12, 2011 – Innovo Publishing LLC released a new title, Carson and His Shaky Paws Grampa, written by Kirk Hall and illustrated by Alison Paolini. Both the author andillustrator live with Parkinson’s disease (PD) as do an estimated 6 million people worldwide, with 50,000–60,000 new cases being diagnosed each year in the U.S. alone. The author—and approximately 10 million other Americans—also lives with another movement disorder called essential tremor (ET).Carson and His Shaky Paws Grampa, Book 1 in the Shaky Paws series, is designed to help parents and grandparents comfortably talk about the initial symptoms of PD and ET and address common questions and concerns children may express. This loving story blends well with Paolini’s charming watercolor illustrations and is written with words simple enough for a child to understand. Based on the author’s personal experience with Parkinson’s and ET, Hall’s approach to this important topic isgentle and effective in reducing concerns with children and younger family members and friends.Carson and His Shaky Paws Grampa not only deals with symptoms of PD and ET, but it touches on an innovative and effective treatment the author successfully underwent called deep brain stimulation (DBS). DBS has resulted in a remarkable quality of life improvement for the author, which he writes about in his book. Carson and His Shaky Paws Grampa is the first book in the planned Shaky Paws Grampa series and will be followed by additional titles that gently explore the more advanced stages of PD.Hall will be showcasing and signing his book at the 6th Annual Southeastern Parkinson Disease Conference in Atlanta, Georgia. The conference begins October 14 and ends on October 16. A portion of the proceeds from the sale of this book will be donated to support Parkinson’s and essential tremor research and awareness.Carson and His Shaky Paws Grampa has been enthusiastically endorsed and supported by a number of Parkinson’s and essential tremor research and philanthropic organizations including the following:“Wonderful story. So warm, thoughtful, and heartfelt. Loved it! A must-read for anyone with ET or PD.” —Catherine S. Rice, Executive Director, International Essential Tremor Foundation “. . . a charming story that provides helpful guidance to PD patients for answering their grandchildren’s innocent questions.” —Margaret Anne Coles, Program Manager,Muhammad Ali Parkinson Center/Barrow Neurological Institute“. . . a fabulous book with remarkable illustrations.” —Cheryl Siefert, Executive Director, Parkinson Association of the Rockies “Great story that touches on DBS surgery and its dramatic positive effects.”—Ben Petrick, former Rockies/Tigers baseball player and Parkinson’s patient who has had DBS surgery“. . . demystifies Parkinson’s for the youngsters in your family.” —Joel Havemann, retired Los Angeles Times editor, author of A Life Shaken: My Encounter with Parkinson’s DiseaseCarson and His Shaky Paws Grampa, Book 1 in the Shaky Paws series, is available now in the U.S.and internationally in hardback (ISBN: 978-1-936076-91-8), paperback (ISBN: 978-1-61314-009-3), Apple iBook for iPad, iPod, and iPhone; Amazon Kindle; Barnes and Noble Nook; and Google Android editions. Large wholesale orders may be read more..
Saturday, 3 March 2012
Calcium Channel Blockers-Parkinson's Disease-Blood Brain Barrier-Dihydropyridine
CCBs that cross the Blood Brain Barrier for PDMost of us read of the California-Denmark study based upon many years of data from which it was observed that some calcium channel blockers have been found to decrease the PD risk factor by about 27%. But what about those who already have Parkinson's?Today we'll skip the toxic dopamine argument between Mosharov and Surmeier etal and just take an actual look at the CCBs in the Dihydropyridine class. Specifically we show the L-type CA(2+) CCBs that can cross the blood brain barrier. Next we'll post the discussions, the disagreement and study links. DIHYDROPYRIDINECALCIUM CHANNEL BLOCKERSAlso known asNotesAmlodipineNorvasc Perivasc, Istin, Agen, Aken Amidipin, Dailyvasc, Lopin,Amcard, AmboletCrosses BBB 3rd generationLipophilic Dihydropyridine May accumulate in brainAranidipineSapresta-AzelnipidineCalblockCrosses BBBscavenges hydroxyl radicalsbut not superxide radicalsReduced levels ofintercellular ROSBarnidipineHypoCa-BenidipineConielmay act in a similar mannerto nimodopineCilnidipineAtelec, Cinalong,Siscard, CilacarCrosses BBBdual blocker of L & N-typecalcium channelsdoes not target proteinkinase CClevidipineCleviprexCrosses BBBultra short acting intravenousCA2+ CBEfonidipineLandelAnother T-type selective CCBsome L-type inhibitionFelodipinePlendilRenedil (in Canada)Crosses BBB2nd generation IsradipineDynaCirc, PrescalCrosses BBB8 hour half-life2nd generationLacidipineMotens, LacipilExhibits high partition coefficients intophosphatidycholineLercanidipineZandipDoes not readily cross BBB3rd generationhas a molecular design which imparts greater solubilitywithin the arterial cellular membrane bilayer, membrane-controlled kinetics and a high cholesteroltolerance factor.MandipineArtedil, Calslot, Manyper, Iperten, MandipotManivasc, Vascoman3rd generationless potential for pedal edema than other CCBsNicardipineCardene, Carden SRCrosses BBBSimilar to Nifedipine2nd generationNifedipineAdalat, ProcardiaApo-Nifed (Canada)Novo-nifedin (Canda)Nu-nifed (CanadaCrosses BBBLipophilic DihydropyridineNilvadipineNivadilBlocks L-type channelsNimodipineNimotop, NIMONimodipinaCrosses BBBsimilar to NifedipineLipophilic DihydropyridineNisoldipineBaymycard, Sular, Syscor-NitrendipineCardif, Baylotensin,Baypress, Deiten,Nidrel, Nitrepin-PranidipineAcalasCarries grapefruit juicewarning as do other CCBsDIHYDROPYRIDINECCBsKnown asNotes read more..